Skills and expertise
- Extensive experience in solid state characterisation and material science, with more than 17 years experience in the Pharmaceutical Industry
- Background in structural organic chemistry
- Proven track record in complex problems solving and trouble shooting of projects, from the Preclinical phase through to Early Development, overseeing material design and development
- Highly experienced in project leading and coordination
- Extensive experience in different therapy areas (respiratory, inflammation, CNS, CV, GI and oncology) and modes of administration; oral, inhalation, parenteral, topical – looking at material property optimisation for the different modes of administration
- Proven ability to work across disciplines and globally
Publications and presentations
Preformulation Predictions from Small Amounts of Compound as an Aid to Candidate Drug Selection, G. Steele, T. K. Austin, In Drugs and the Pharmaceutical Sciences Vol. 199, Pharmaceutical Preformulation and Formulation: A Practical Guide from Candidate Drug Selection to Commercial Dosage Form. 2nd Edition. Ed. M Gibson Chapter 3, pp17-128, Informa Healthcare, New York (2009)
Characterization of a Polymorphic System Exhibiting Substantial Variation of Solubility in a Fluorinated Solvent, M Côte, C. E. Hughes, T. K. Austin, P. G. A. Rogueda, Z. Pan, K. D. M. Harris, P. C. Griffiths, J. Phys. Chem. C, (2008), 112(37), 14570
Understanding the polymorphic behavior of sibenadet hydrochloride through detailed studies integrating structural and dynamical assessment, S. D. Cosgrove, G. Steele, T. K. Austin, A. P. Plumb, B. Stensland, E. Ferrari, K. J. Roberts, J. Pharm. Sci., (2005), 94(11), 2403
Novel Piperidine derivatives, T. Austin, D. O’Sullivan, M. Perry, B. Springthorpe, PCT Int Appl 2007, WO 2007011293
Investigations into the amorphous and crystalline forms of a development compound, D. O’Sullivan, G. Steele & T. K. Austin, Proceedings in amorphous food and pharmaceutical systems, p220-230 (ed H. Levine), Royal Society of Chemistry, Special Publication No. 281, Cambridge (2002)
Understanding relative polymorph stability through structure and thermodynamics, invited talk at the British Crystallographic Association Autumn 2007 meeting, AstraZeneca Alderley Park, November 2007
Challenges in controlling solubility & dissolution by chemical & material design invited talk at IQPC Pharma IQ conference on Improving solubility in drug candidates, Philadelphia PA, September 2006
Assessment of Physical Impurities Using a Range of Solid-state Techniques, invited talk at the Pharmaceutical Analysis Support Group Meeting, Northampton UK, April 2005
Some Applications of Solid State NMR Spectroscopy in the Pharmaceutical Industry, poster presentation at the ACS Prospectives Polymorphism In Crystals Conference, Tampa Florida, February 2003
The solid state characterisation of AR-C 69457AA, invited talk at the Thermal Analysis and Calorimetry Conference (TAC) 2000, Loughborough University, April 2000
Investigations into the amorphous and crystalline forms of a development compound, poster presentation at the Thermal Analysis and Calorimetry Conference (TAC) 2000, Loughborough University – winning first prize for poster presentations, April 2000
The Solid State Characterisation of AR-C69457AA – a Novel D2/β2 Agonist, poster presentation at the International Conference on the Organic Solid State XIV, University of Cambridge, July 1999